Posted: 09 September 2011
Alfin-Slater RB: Pi-Sunyer FX. Sugar and sugar substitutes. Comparisons and indications. Postgrad Med 1987 Aug;82(2):46-50,53-6
As Aspartame proliferates in products, controversy over safety won't die. Environ Nutr. 1987 Jan;10(1):1.4
Aspartamea bit of a headache? Food Chem. Toxicol 1988:26(6): 571
Aspartame and headache [letter]. N Engl J Med 1988 May 5; 318(18):1200-2
Aspartame intolerance. Nutr. Res. NewsL 1989 Feb:8(2); 15
[Aspartame]. Levnedsmiddclstyrelscn 1987; 144(35p.) [Dan]
Aune T. [Artificial sweeteners: current evaluation]. Nor Veterinaertidsskr 1987; 101(3):195-6 [Nor]
Balasubramanyam BV. Aspartame- the new artificial sweetener. Indian Diaryman 1989; 41(11): 576-7
Barinaga M. MSG: a 20-year debate continues. Science 1990 Jan 5; 247(4938);21
Bickel H: Trefz FK. [Aspartame: a sweetening agent with a high phenylalanine content]. Monatsschr Kinderhielkd 1986 Jul; 134(7): 478-80 [Ger]
Blundell JE; Hill AJ. Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet 1986 May 10;1;1092-3
Bradstock MK; Serdula MK; Marks JS; Barnard RJ; Crane NT; Remington PL; Trowbridge FL;. Evaluation of reactions to food addictives: the aspartame experience. Am J Clinic Nutr. 1986 Mar, 43 (3): 464-9
Braverman ER. Can aspartame cause headaches? Total Health 1990 Aug; 12(4):57
Brownlee S. The anatomy of a headache. US News Word Rep 1989 Jul 31; 107(5):46
Caltero B; Mahon BE; Rohr FJ; Levy HL; Wurtman RJ. Plasma amino acid levels after single-dose aspartame consumption in phenylktonuria, mild hyperphenylalaninemia, and heterozygous state Phenylketonuria. J Pediatr. 1986;109(4): 668-71
Coulombe RA Jr; Sharma RP. Neurobiochemical alterations induced by artificial sweetener aspartame (NutraSweet). Toxicol Appl Pharmacol 1986; Mar 30;83(1);79-85
Davoli E; Cappelini L; Airoldi L; Fanelli R. Scrum methanol concentrations in rats and in men after a single dose of aspartame. Food Chem Toxicol 1986;24(3):187-9
Ditte C. [ Bibliographic study of the toxicity of three sweeteners]. Built Soc Pharm Lille 1988;44(2-3): 3-40 [Fre]
Dow-Edwards DL; Scribani LA; Riley EP. Impaired performance on odor aversion testing following prenatal aspartame exposure in the guinea pig. Neurotoxicol Teratol 1989 Jul-Aug; 11(4) ;413-6
Drake ME. Panic attacks and excessive aspartame ingestion[letter]. Lancet 1986 Sep 13;2(8507):631
Drenth JO; Kleinjans JC. [Aspartame, a sweet alternative]. Ned Tijdschr Geneeskd 1988 Apr 16; 132(16); 712-5 [Dul]
Edmeads J. Aspartame and headache. Headache 1988 Feb; 28(1);64-5
Effects of sugar on mood. Nutr Res News 1990 Apr; 9 (4); 46A
Elsas LJ 2d; Trotter JF. Changes in physiological concentrations of blood phenylalanine produce changes in sensitive parameters of human brain function. In; Wurtman, R. J.; Ritter-Walker, E, editors. Dietary phenylalanine and brain function. Boston; Birkhauser. 1988. p.187-95
Farber SA. The price of sweetness. ( Safety and effectiveness of sugar substitutes). Technol Rev 1990 Jan; 93(1);46
Ferguson HB; Stoddart C; Simeon JG. Double blind challenge studies of behavioral and cognitive effects of sucrose-aspartame ingestion in normal children. Nutr Rev 1986 May;44 Suppl; 144-50
Folkenberg J. Reporting reactions to additives. Dairy Food Sanitat 1989;9(9); 500-1
Food additives: concerns and adverse reactions. Sem Nutr 1987 Nov-Dec;7 (2); 1-18
Fountain SB; Hennes SK; Teyler TJ. Aspartame exposure and in vitro hippocampal slice excitability and plasticity. Fundam Appl Toxicol 1988 Aug 11 (2): 221-8
Franz M. Is it safe to consume aspartame during pregnancy? A review. Nutrition update. Diabetes Educ 1986 Spring; 12 (2); 145-7
Franz M. Is it safe to consume aspartame during pregnancy? Review. Palmetto Pharm 1986 Dec; 25:21-3
Franz MJ. Aspartame does not cause headaches. Diabetes News 1989 Sep-Oct; 6 (5); 51
Freedman M. Consumption of aspartame by heterozygotes for Phenylketonuria [letter]. Pediatr 1987 Apr,110(4):662-3
Fricker J. [Are sweeteners really anodyne?] Recherche 1989;214;1260-2 [Fre]
Galland MC; Comuce C; Bourdillon N. [ Chinese restaurant syndrome. Implication of drugs] Therapie 1987 May-Jun; 42(3):291-4 [Fre]
Garaltill S ; Caccia S; Romano M; Diomede L; Guis G; Vezzani A; Salmona M. Studies on the susceptibility to convulsions in animals receiving abuse doses of aspartame. In; Wurtman, R.J.; Ritter-Walker, E., editors. Dietary phenylalanine and brain function. Boston; birkhauser; 1988. p.131-43
Gayte-Sorbier A. [ Sweetener: sugar and substitutes] Rev Fr Diet 1986; 30(117):3-7
Germanyuk YL. [Artificial sucrose substitutes in diseases accompanied by disorders in carbohydrate and lipid metabolism]. Vrach Delo 1986; (8): 63-7 [Rus]
Gershbein LL; Dachman A; Gershbein JD; Rao KC. Behavioral and hepatic microsomal studies of rats administered sweetening agents. Res Commun Psychol Psychiatr Behav 1987; 12(3): 151-68
Guiso G.; Caccia S; Vezzani A; Stasi MA; Salmona M; Romano M; Garattini S. Effect of aspartame on seizures in various models of experimental epilepsy. Toxicol Appl Pharmacol 1988 Dec; 96(3); 485-93
Gupta V.; Cochran C; Parker TF; Long DL; Ashby J; Gorman MA; Liepa GU. Effect of aspartame on plasma amino acid profiles of diabetic patients with chronic renal failure. Am J Clin Nutr 1989 Junn;49(6): 1302-6
Hattan D. Toxicological and nutritional evaluation of low nutrition density foods. In: Walker R.; Quattrucci, P., editors. Nutritional and toxicological aspects of food processing; proceedings of an international symposium held at the istituto Superiore di Sanita; 1987 Apr 14-16; Rome London: Taylor & Francis; 1988. p.275-91
Heraud G. [ The sweeteners]. Cah Nautr Diet 1986; 21(1) 65-70 [Fre]
High intensity sweeteners. Food Rev 1987; 14(4): 35.37
Holder MD. Effects of perinatal exposure to aspartame on rat pups. Neurotoxicol Teratol 1989 Jan-Feb; 11(1): 1-6
Holder MD; Yirmiya R. Behavioral assessment of the toxicity of aspartame. Pharmacol Biochem Behave 1989 Jan; 32(1):17-26
Jacknowitz AL. Artificial sweeteners: how safe are they? US Pharm 1988 Jan ;13: 28,30, 31
Janssen PJ; van der Heijden CA. Aspartame; review of recent experimental and observational data. Toxicology 1988 Jun; 50(1): 1-26
Johansson B. [ Deleterious effects of aspartame]. Var Foeda 1988;40(6):311-2 [Swe]
Johns DR. Aspartame and headache. In: Wurtman, R. J; Ritler-Walker , E., editors. Dietary phenylalnine and brain function. Boston ; Birkhauser; 1988 p.303-12
Johns DR. Migraine provoked by aspartame [letter] N Engl J Med 1986 Aug 14; 315(7):456
Josephson P; Josephson IL; Breum L. [Aspartame] Ugeskr Laeger 1988 Jun 13;150(24):1455-9 [Dan]
Kiritsy PJ; Maher TJ. Acute effects of aspartame on systolic blood pressure in spontaneously hypertensive rats. J Neural Transm 1986;66(2):121-8
Koehler SM. The effect of aspartame consumption on migraine headache; preliminary results. In: Wurtman , R. J.: Ritter-Walker, E., editors. Dietary phenylalanine and brain functions. Boston: Birkhauser, 1988,p.313-6
Koehler SM; Glaros A. The effect of aspartame on migraine headache. Headache 1988 Feb; 28(1): 10-4
Kronick JB; Whelan DT; McCallion DJ. Experimental hyperphenylalaninemia in the pregnant guinea pig: possible phenylalanine teratogenesis and pchlorophenylalanine embryotoxicity. Teratology 1987;36:245-58
Kulczycki A Jr. Aspartame induced urticaria. Ann Intern Med 1986 Feb;104(2): 207-8
Lapierre KA; Greenblatt DJ; Goddard JE; Harmatz JS; Shader RL. The neuropsychiatric effects of aspartame in normal volunteers. J Clin Pharmacol 1990 May; 30(5): 454-60
Lehmann A; Hamberger A. [The sweetening agent aspartame a health risk?] Lakartidningen 1988 Jul 27;85(30-31): 2453-4
Leon AS; Hunninghake DB; Bell C; Rassin DK; Tephly TR. Safety of long-term large doses of aspartame. Arch Intern Med 1989 Oct; 149 (10) 2316-24
Lieberman HR; Caballero B; Emde GG; Bernstien JG; The effects of aspartame on human mood performance and plasma amino acid levels. In: Wurtman, R. J,; Ritter-Walker. E., editors. Dietary phenylalnine and brain function. Boston Birkhauser, 1988.p.196-200
Lipton RB. Aspartame and headache. Nutr Res Newsl 1989 May 8(5):54
Lipton RB; NewmanLC; Cohen JS; Soloman S. Aspartame as dietary trigger of headache. Headache 1989 Feb;29(2);90-2
Lipton RB; Newman LC; Soloman S; Stienmetzer RV; Kunkel RS; Elsas LJ II; Schiffman SS; Buckley CE; Sampson HA; Massey EW. Aspartame and headache, N Engl J Med 1988 May 5; 318(18):1200-2
Lout RK; Messer LB; Soberay A; Kajander K; Rudney J. Cariogenicity of frequent aspartame and sorbitol rinsing in laboratory rats. Caries Res 1988 22(4): 237-41
Maher TJ> Natural food constituents and additives; the pharmacologic connection. J Allergy Clin Immunol 1987 Mar: 79(3):413-22
Maher TJ. Neurotoxicology of food additives. Neurotoxicology 1986 Summer,7(2):183-96
Maher TJ; Wurtman RJ. Possible neurologic effects of aspartame, a widely used food additive. Environ Health Perspect 1987 Nov; 75:53-7
Moneret- Vautrin DA: Petithory D. [Allergy risks from food technology and consumption of new products]. Med Nutr 1987;23(4):217-24 [Fre]
Nabors LO. Saccharin and aspartame. Are they safe to consume during pregnancy? [letter] . J Reprod Med 1988 Aug;33(8):102
Nabors, L.O.; Gelardi, R.C., editors, Alternative sweeteners. New York: M. Dekker, Inc: 1986. 355p.
Nevins ME; Arnolde SM; HaiglerHJ. Aspartame: lack of effect on convulsant thresholds in mice. UCLA Symp Mol Cell Biol 1987; NS55;437-50
Noirfalise A. [Sweeteners toxicological aspects]. Belg J Food Chem Biotechnol 1987; 41(6):155-60 [Fre]
Okholm L. [Aspartame its status following 20 years of toxicology studies]. Tandlaegebladet 1987 Aug;91(11):493-7 [Dan]
Pagliaro LA: Locock RA. Aspartame. Can Pharm J 1986 Mar;119:121-5
Pan-Hou H; Suda Y; Ohe Y; Sumi M; Yoshioka M. Effect of aspartame on N-methyl-Daspartate-sensitive triliated L-glutamate binding sites in brain synaptic membranes. Brain Res 1990;520(1-2):351-3
Pardridge WM. Dietary phenylalanine and brain function. J Appl Nutr 1987;39(2);94-6
Pardridge WM. Potential effects of the dipeptide sweetener aspartame on the brain. Nutr Brain 1986;7:199-241
Pardridge WM. The safety of aspartame [letter]. JAMA 1986 Nov 21;256(19):2678
Pardridge WM. The safety of aspartamereply. JAMA 1987;258:206
Perego C; De Simoni MG; Fodritto F; Raimondi L; Diomede L; Salmona M; Algeri S; Garrattini S. Aspartame and the rat brain monoaminergic system. Toxicol Lett 1988;44(3):331-9
Pinto JM: Maher TJ. Administration of aspartame potentiates pentylenetetrazole- and fluorothyl induced seizures in mice. Neuropharmacology 1988 Jan;27(1):51-5
Pivonka EE; Grunewald KK. Aspartame or sugar sweetened beverages; Effects on mood in young woman. J Am Diet Assoc 1989 Feb;90(2);250-4
Potenza DP; el-Mallakh RS. Aspartame: clinical update Conn Med 1989 Jul;53(7):395-400
Roberts HJ. Aspartame (NutraSweet) is it safe? Philadelphia: Charles Press; 1990. 315p.
Roberts HJ. Aspartame, tryptophan, and other amino acids as potentially hazardous experiments [letter]. South Med J 1990;83(9):1110-1
Roberts HJ. Neurological, psychiatric, and behavioral reactions to aspartame in 505 aspartame reactions. In: Wurtman, R.J.; Ritter-Walker. E., editors. Dietary phyenylalanine and brain function. Boston: Birhauser; 1988. p.373-6
Rosetta L. Sweeteners: nutritive and non-nutritive. Food Technol 1986;40(8):195-206
The safety of aspartame. Nutr MD 1986 Sept;12(9):1
Sandstead HH: Anderson GH; Hrboticky N; Spring BJ; Lieberman HR; Swope G; Garfield GS; Atkins FM; Ferguson HB; Stoddart C; et al. Dict and behavior , a multidisciplinary evaluation. Proceedings of a symposium November 27 to 29, 1984 Arlington, Virginia. Nutr Rev 1986;44 Suppl: (254p.)
Saravis S.; Schacher R; Zlotkin S; Leiter LA; Anderson GH. Aspartame; Effects on learning, behavior and mood. Pediatrics 1990; 86(1):75-83
Sardecai VM; Holiday JF; Kumar GK; Dunbar JC. Effect of aspartame in normal and diabetic rats. Biochem Arch 1986;2(4):237-44
Shaban HM; Albert ML. Aspartame evaluation of adverse effects. Hosp Formul 1988 Jun;23:543-6
Sharma RP; Coulombe RA Jr. Effects of repeated doses of aspartame on serotonin and metabolic in various regions of the mouse brain. Food Chem Toxicol 1987; 25 (8):565-8
Simon RA. Adverse reactions to the additives. N Engl Reg Allergy Proc 1986 Nov-Dec;7(6):533-42
Spiers P; Schomer D; Sabounjian L; Lieberman H; Wurtman R; Dugguid J; McCarten R; Lyden M. Aspartame and human behavior cognitive and behavioral observations. In: Wurtman, R. J; Ritter-Walker, E., editors. Dietary phenylalanine and brain function. Boston: birkhauser; 1988.p.169-78
Szucs Ef; Barrett KE; Metcalfe DD. The effect of aspartame on mast cells and basophilis. Food Chem Toxicol 1986;24(2);171-4
Tatco F; Berte F; Bianchi A; Bianchi L. [Technological and toxicological problems with formulation of low calorie products. I. Data on the aspartame.]. Riv Soc Ital Sci Aliment 1989;18(1);17-22 [Ita]
Tatco F; Berte F; Bianchi A; Gregotti C; Richelmi P. [Reactivity of aspartame with aldehydes in flavourings; technological and toxicological aspects. Riv Soc Ital Sic Aliment 1986;15(1-2):23-34 [Ita]
Tatco F; Triangeli L; Ciserchia E; et al. [Reactivity of aspartame with carbonyl compounds present in foods. IIJ. Boll Chim Farm 1986 Nov 125(11);404-9 [Ita]
Tobey NA; Heizer WD. Instetinal hydrolysis os aspartylphenylalanine- the metabolism product of aspartame. Gastroenterology 1986 Oct;91(4);931-7
Tordoff MG; Alleva Am. Oral stimulation with aspartame increases hunger. Physiol Behav 1990;47(3); 555-9
Torii K; Mimura T; Takasaki Y; Ichimura M;. Dietary aspartame with the protein on plasma and brain amino acids, brain monoamines and behavior rats. Physiol Behav 1986;36(4); 765-72
Torii K; Mimura T; Takasaki Y; Ichimura M. Effect of mealing on plasm and brain amino acid and brain monoamines in rats after oral aspartame. Physiol Behav 1986;36(4):759-64
Van Horssen N; Van Der ZandenAK; Verheoven J. [Aspartame : new sweetener in pharmaceutical products]. Phar Weekbl 1987 Jun12;122;73-9 [Dut]
Van Velzen A. [ Aspartame a sweet alternative]. Ned Tijdschr Geneeskd 1988 Jul 30;132(31);1452 [Dut]
Vettorazzi G. [Development of sugar substitutes; a comparison from toxicological and nutritional points of view]. Alimentaria 1986;23;9(176):17-28
Vial T; Sapori JM; Descotes J. [Undesirable effects of aspartame]. Concours Med 1990;112(3);235-7 [Fre]
Vidaud Candebat ZE; Garcia Roche M. [ Action, use analysis, and toxicity of the artificial sweeteners of current or potential use in Cuba]. Alimentaria 1989;26(204);47-52 [Spa]
Walton, RG, The possible role of aspartame in seizure induction. In: Wurtman, R. J.; Ritter-Walker, E. editors. Dietary Phenylalanine and brain function. Boston: Birkhauser, 1988. p. 159-62
Walton RG.. Seizure and mania after high intake of asparatame. Psychosomatics 1986 Mar;27 (3); 218, 220
Wei CI: Tan H; Wheeler WB. Reaction of chlorine dioxide with amino acids and peptides; kinets and mutagenicity studies. Environ Mutagen 1987; 9 Suppl 8;112
Wurtman RJ; Maher TJ. Effects of oral aspartame on plasma phenylalanine in human and experimental rodent. J Neural Transm 1987;70(1-2):169-74
Wurtman RJ; Maher TJ. General discussion: Calculation of the aspartame dose for rodents that produce neurochemical effects comparable to those occurring in people. In: Wurtman, R. J.: Ritter-Walker, E. editors. Dietary phenylalanine and brain function. Boston: Birkhauser; 1988. p.144-8
Yim:iya R: Levin ED: Chapman CD; Garcia J. Morphological and behavioral effects of perinatal exposure to aspartame (NutraSweet ) on rat pups. Bull Psychon Soc 1989:27 (2);153-6
Zametkin AJ; Karoum F; Rapoport JL. Treatment of hyperactive children with D-phenylalanine. Am J Psychiatry 1987 Jun;144(6):792-4
Dr. Betty Martini, D.Hum.
Founder, Mission Possible World Health International
9270 River Club Parkway
Duluth, Georgia 30097
770-242-2599
E-Mail: BettyM19@mindspring.com
http://www.wpwhi.com
http://www.wnho.net
http://www.dorway.com
Aspartame Toxicity Center: http://www.holisticmed.com/aspartame