By Dr. Betty Martini, D.Hum.
Mission Possible International
9270 River Club Parkway
Duluth, Georgia 30097
Telephone: 770-242-2599
Web Site:

Posted: 09 September 2011

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Blundell JE; Hill AJ. Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet 1986 May 10;1;1092-3

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Guiso G.; Caccia S; Vezzani A; Stasi MA; Salmona M; Romano M; Garattini S. Effect of aspartame on seizures in various models of experimental epilepsy. Toxicol Appl Pharmacol 1988 Dec; 96(3); 485-93

Gupta V.; Cochran C; Parker TF; Long DL; Ashby J; Gorman MA; Liepa GU. Effect of aspartame on plasma amino acid profiles of diabetic patients with chronic renal failure. Am J Clin Nutr 1989 Junn;49(6): 1302-6

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Jacknowitz AL. Artificial sweeteners: how safe are they? US Pharm 1988 Jan ;13: 28,30, 31

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Johns DR. Migraine provoked by aspartame [letter] N Engl J Med 1986 Aug 14; 315(7):456

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Koehler SM. The effect of aspartame consumption on migraine headache; preliminary results. In: Wurtman , R. J.: Ritter-Walker, E., editors. Dietary phenylalanine and brain functions. Boston: Birkhauser, 1988,p.313-6

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Kronick JB; Whelan DT; McCallion DJ. Experimental hyperphenylalaninemia in the pregnant guinea pig: possible phenylalanine teratogenesis and pchlorophenylalanine embryotoxicity. Teratology 1987;36:245-58

Kulczycki A Jr. Aspartame ­induced urticaria. Ann Intern Med 1986 Feb;104(2): 207-8

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Lipton RB. Aspartame and headache. Nutr Res Newsl 1989 May 8(5):54

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Lipton RB; Newman LC; Soloman S; Stienmetzer RV; Kunkel RS; Elsas LJ II; Schiffman SS; Buckley CE; Sampson HA; Massey EW. Aspartame and headache, N Engl J Med 1988 May 5; 318(18):1200-2

Lout RK; Messer LB; Soberay A; Kajander K; Rudney J. Cariogenicity of frequent aspartame and sorbitol rinsing in laboratory rats. Caries Res 1988 22(4): 237-41

Maher TJ> Natural food constituents and additives; the pharmacologic connection. J Allergy Clin Immunol 1987 Mar: 79(3):413-22

Maher TJ. Neurotoxicology of food additives. Neurotoxicology 1986 Summer,7(2):183-96

Maher TJ; Wurtman RJ. Possible neurologic effects of aspartame, a widely used food additive. Environ Health Perspect 1987 Nov; 75:53-7

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Nevins ME; Arnolde SM; HaiglerHJ. Aspartame: lack of effect on convulsant thresholds in mice. UCLA Symp Mol Cell Biol 1987; NS55;437-50

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Pan-Hou H; Suda Y; Ohe Y; Sumi M; Yoshioka M. Effect of aspartame on N-methyl-Daspartate-sensitive triliated L-glutamate binding sites in brain synaptic membranes. Brain Res 1990;520(1-2):351-3

Pardridge WM. Dietary phenylalanine and brain function. J Appl Nutr 1987;39(2);94-6

Pardridge WM. Potential effects of the dipeptide sweetener aspartame on the brain. Nutr Brain 1986;7:199-241

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Pardridge WM. The safety of aspartame­reply. JAMA 1987;258:206

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Pinto JM: Maher TJ. Administration of aspartame potentiates pentylenetetrazole- and fluorothyl induced seizures in mice. Neuropharmacology 1988 Jan;27(1):51-5

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Shaban HM; Albert ML. Aspartame evaluation of adverse effects. Hosp Formul 1988 Jun;23:543-6

Sharma RP; Coulombe RA Jr. Effects of repeated doses of aspartame on serotonin and metabolic in various regions of the mouse brain. Food Chem Toxicol 1987; 25 (8):565-8

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Dr. Betty Martini, D.Hum.
Founder, Mission Possible World Health International
9270 River Club Parkway
Duluth, Georgia 30097

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