Posted: 01 August 2012
Early poor memory in multiple sclerosis, and other studies, Andreas Plaitakis et al, University of Crete, Heraklion, Greece -- fits Monte methanol/formaldehyde paradigm: Rich Murray 2012.07.18
http://rmforall.blogspot.com/2012/07/early-poor-memory-in-multiple-sclerosis.html
Behav Neurol. 2012 Feb 15. [Epub ahead of print]
Early signs of memory impairment among multiple sclerosis patients with clinically isolated syndrome.
"Besides smoking, alcohol drinking and vitamin intake was more common among female patients with MS."
[Affluent urban women who drink alcohol and buy vitamins are more likely to use fancy liquors with high methanol and aspartame diet drinks and foods -- one pack of cigarettes or 1 litre aspartame diet drink give about the same amount of methanol, 63 mg -- rural poorer women may be exposed to more methanol from wood fires and smoked fish and meats]
[657 cases in Crete, population 0.6 million, about 110 cases per 100,000]
Neurology. 2012 May 29;78(22):1728-35. Epub 2012 May 16.
Rising incidence of multiple sclerosis in females associated with urbanization.
"These data provide strong evidence that hemodynamic changes -- affecting both white and DGM -- may occur even at the earliest stage of multiple sclerosis, with CIS patients being significantly different than relapsing-remitting multiple sclerosis patients."
http://onlinelibrary.wiley.com/doi/10.1002/mrm.24194/abstract
White matter and deep gray matter hemodynamic changes in multiple sclerosis patients with clinically isolated syndrome
Behav Neurol. 2012 Feb 15. [Epub ahead of print]
Early signs of memory impairment among multiple sclerosis patients with clinically isolated syndrome.
Panou T, Theodora Panou, Mastorodemos V, Papadaki E, Efrosini Z. Papadaki , Simos PG, Plaitakis A. Andreas Plaitakis
Department of Neurology, Faculty of Medicine, University of Crete, Heraklion, Greece.
Abstract
The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and compared them to 49 patients with relapsing remitting MS (RR-MS) displaying mild disability and to a large cohort of age- and education level-matched healthy volunteers (n=230). Results showed that both CIS and RR-MS patients evidenced a disproportionate impairment in the immediate and delayed recall of the second (as compared to the first) of two short narratives of the Logical Memory WMS-III subtest, and reduced performance on the Memory for Digits-Forward. Performance of either group on the executive tasks was not impaired, showing evidence of a reversed speed-accuracy trade-off. Illness duration emerged as a significant predictor of memory and executive task performance. Clinical, psychoemotional, and brain imaging findings were also examined as potential correlates of memory deficits and disease progression among CIS patients. These findings may signify early-onset decline of specific cognitive functions in CIS, which merits regular follow-up assessments and monitoring of psychoemotional adaptation and everyday functioning. PMID: 22713377
"Besides smoking, alcohol drinking and vitamin intake was more common among female patients with MS."
[Affluent urban women who drink alcohol and buy vitamins may be more likely to use cigarettes, fruits juices vegetables preserved wet in cans jars plastics, fancy liquors with high methanol, and aspartame diet drinks and foods -- one pack of cigarettes or 1 litre aspartame diet drink gives about the same amount of methanol, 63 mg , while poorer rural women may be exposed to more methanol from wood fires.]
.
Neurology. 2012 May 29;78(22):1728-35. Epub 2012 May 16.
Rising incidence of multiple sclerosis in females associated with urbanization.
Kotzamani D, Panou T, Mastorodemos V, Tzagournissakis M, Nikolakaki H, Spanaki C, Plaitakis A.
Correspondence & reprint requests to Dr. Plaitakis:Neurology. 2012 May 29;78(22):1728-35. Epub 2012 May 16.
Rising incidence of multiple sclerosis in females associated with urbanization.
Kotzamani D, Panou T, Mastorodemos V, Tzagournissakis M, Nikolakaki H, Spanaki C, Plaitakis A.
Abstract
OBJECTIVE:
To design and perform a case-control study of multiple sclerosis (MS) in Crete, an island of 0.6 million people, that has experienced profound socioeconomic changes in recent decades.
METHODS:
All MS cases occurring on Crete from 1980 to 2008 were ascertained. To search for putative risk factors, a structured questionnaire of 71 variables was employed, with patients with MS (n = 657) being compared to random controls (n = 593) matched for age, gender, and current place of residence.
RESULTS:
MS incidence rose markedly on Crete over the past 3 decades. This increase was associated with a major shift in MS distribution among genders (1980: F/M = 0.9; 2008: F/M = 2.1), with females living in towns or having relocated at a young age from the countryside to urban centers being mainly affected. In rural Crete, MS showed lesser increases and gender preference. Of the major changes that accompanied urbanization, smoking among women with MS increased dramatically, while imported pasteurized cow milk virtually replaced fresh goat milk produced locally. Compared to controls, female patients with MS more often used contraceptives and were older at first childbirth. Besides smoking, alcohol drinking and vitamin intake was more common among female patients with MS. Also, the distribution of childhood diseases and chronic medical conditions differed significantly between patients with MS and controls.
CONCLUSIONS:
MS incidence rose markedly over 3 decades in a genetically stable population in tandem with a transition from rural to urban living, thus possibly implicating environmental factors introduced by urbanization.
PMID: 22592376.
"These data provide strong evidence that hemodynamic changes -- affecting both white and DGM -- may occur even at the earliest stage of multiple sclerosis, with CIS patients being significantly different than relapsing-remitting multiple sclerosis patients."
http://onlinelibrary.wiley.com/doi/10.1002/mrm.24194/abstract
White matter and deep gray matter hemodynamic changes in multiple sclerosis patients with clinically isolated syndrome
Efrosini Z. Papadaki 1,†,*, Efrosini Z. Papadaki, Vasileios C. Mastorodemos 2,
Emmanouil Z. Amanakis 1, Konstantinos C. Tsekouras 1, Antonis E. Papadakis 3,
Nikolaos D. Tsavalas 1, Panagiotis G. Simos4, Apostolos H. Karantanas1, Andreas Plaitakis 2, Thomas G. Marism 3
Article first published online: 24 FEB 2012
DOI: 10.1002/mrm.24194
Copyright © 2012 Wiley Periodicals, Inc.
Issue
Magnetic Resonance in Medicine
Early View (Online Version of Record published before inclusion in an issue)
Papadaki, E. Z., Mastorodemos, V. C., Amanakis, E. Z., Tsekouras, K. C., Papadakis, A. E., Tsavalas, N. D., Simos, P. G., Karantanas, A. H., Plaitakis, A. and Maris, T. G.
(2012), White matter and deep gray matter hemodynamic changes in multiple sclerosis patients with clinically isolated syndrome.
Magn. Reson. Med.. doi: 10.1002/mrm.24194
Author Information
Abstract
The dynamic susceptibility contrast magnetic resonance imaging perfusion technique was used to investigate possible hemodynamic changes in normal appearing white matter and deep gray matter (DGM) of 30 patients with clinically isolated syndrome (CIS) and 30 patients with relapsing-remitting multiple sclerosis. Thirty normal volunteers were studied as controls. Cerebral blood volume, cerebral blood flow (CBF), and mean transit time values were estimated. Normalization was achieved for each subject with respect to average values of CBF and mean transit time of the hippocampi's dentate gyrus. Measurements concerned three regions of normal white matter of normal volunteers, normal appearing white matter of CIS and patients with relapsing-remitting multiple sclerosis, and DGM regions, bilaterally. All measured normal appearing white matter and DGM regions of the patients with CIS had significantly higher cerebral blood volume and mean transit time values, while averaged DGM regions had significantly lower CBF values, compared to those of normal volunteers (P < 0.001). Regarding patients with relapsing-remitting multiple sclerosis, all measured normal appearing white matter and DGM regions showed lower CBF values than those of normal volunteers and lower cerebral blood volume and CBF values compared to patients with CIS (P < 0.001). These data provide strong evidence that hemodynamic changes -- affecting both white and DGM -- may occur even at the earliest stage of multiple sclerosis, with CIS patients being significantly different than relapsing-remitting multiple sclerosis patients.
Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
Factors Associated with a Steep Rise in the Incidence of MS on Crete over the past 25 Years
Author(s): Theodora Panou, Maria Mylonaki, Dimitra Kotzamani, Gregory Chlouverakis, Vasileios Mastorodemos, Andreas Plaitakis, Heraklion, Greece
OBJECTIVE:
To search for factors that could account for the steep rise of MS in the population of Crete over the past 25 years.
BACKGROUND:
We have previously reported (Neurology ,66; A228, Suppl. 2, 2006) that MS incidence on Crete increased steadily from 1980 to 2006, following profound socioeconomic changes in this population. These observations suggest exogenous factors as the main determinants.
DESIGN/METHODS:
Here we performed a prospective study that explored potential risk factors using a breakthrough paradigm by WC Monte: methanol is made by ADH1 enzyme into hydrated formaldehyde right within cells in middle layer of human brain blood vessel walls at base of brain, the perivascular loci for MS: Rich Murray 2012.07.18
WC Monte paradigm -- multiple sclerosis caused by methanol being made into formaldehyde inside cells of brain blood vessel walls by ADH1 enzyme: Rich Murray 2012.07.18
Textbook, and free articles, published journal paper, and 745 free online full text PDF medical research references, along with audio and video media:
http://www.WhileScienceSleeps.com
http://www.youtube.com/user/whilesciencesleeps
19 video talks
Methanol (wood alcohol) has many sources:
aspartame, E951
smoke from wood, peat, cigarettes
fruits juices vegetables, especially tomatoes, sealed wet in cans, jars, plastic bags, at room temperature
many dark wines and liquors (fruit brandy is worst)
fermented, smoked, spoiled foods
fresh tomatoes, black currants
jellies, jams, and marmalades not made fresh and kept refrigerated
chewing gum
bacteria in the colon
genetic flaws in metabolism
vehicle fumes
processed wood products of all kinds
factories making leather, paper, particle board and plywood, or using solvents
mobile homes
within mutual service, Rich Murray
Methanol from aspartame, wood and cigarette smoke, and many sources is made by ADH1 enzyme into formaldehyde within cells inside walls of human blood vessels, harming adjacent tissues, the WC Monte paradigm: Rich Murray 2012.07.18
The 200 mg aspartame in a 12-oz can of aspartame drink is 11% by weight methanol, 22 mg, which is soon released from the GI tract into the blood, where quickly any tissues with high levels of the ADH1 enzyme within the cells of blood capillary walls and adjacent tissues, especially liver, kidney, brain, retina, etc., in humans only, turn the methanol into formaldehyde within these cells, which, being highly reactive, quickly binds with and disables DNA, RNA, and proteins inside the cells, causing cell death, attracting macrophages (white blood cells), which also die, creating durable, cumulative, evolving complex micro lesions.
This affects the fetus, as well, or not so well...
So, there are many resulting novel modern "diseases of civilization" in humans only, for each type of damaged tissue, including Alzheimer's, multiple sclerosis, lupus, arthritis, the birth defects spina bifida, autism, and Asperger's, many specific cancers, and chronic ailments of liver, kidney, heart, lung, joint, skin, muscle, etc.
The Monte methanol/formaldehyde toxicity paradigm MMFTP is backed by 740 references, given free online as full PDF texts by Prof. (retired 2004, Arizona State University, Nutrition and Food Sciences) Woodrow C. Monte, http://www.WhileScienceSleeps.com, along with his 2012 January 240 page text "While Science Sleeps", with two free chapters on "Autism and Other Birth Defects", and "Multiple Sclerosis", and free full earlier articles and references on MMFTP.
Other methanol/formaldehyde sources include wood, peat and cigarette smoke, some fresh coffees, fermented and smoked foods, fruits juices vegetables heated and sealed wet in jars and cans, some dark wines and liquors, bacteria in the colon, genetic flaws in metabolism, vehicle fumes, leaky fossil fuel stoves and heaters, processed wood products of all kinds, mobile homes, old Ditto type purple ink mimeograph duplicating machines in schools and offices, chemical biology autopsy mortuary facilities, heated wood in particleboard, pressed wood and paper factories, and many personal care cleaners and products...
Methanol/formaldehyde paradigm for multiple sclerosis, free full 56 page chapter 9 PDF, While Science Sleeps, 146 full text references online, Prof. Woodrow C. Monte: Rich Murray 2012.03.20
http://rmforall.blogspot.com/2012/03/methanolformaldehyde-paradigm-for.html
http://www.whilesciencesleeps.com/references
List of 745 free full text PDF medical research references
Aspartame: The hidden danger [methanol/formaldehyde] in our midst and how it kills us, 12 page review of While Science Sleeps text (Woodrow C Monte), International Health News, whole June issue, Editor: William R Ware PhD: Rich Murray 2012.06.08 http://rmforall.blogspot.com/2012/06/aspartame-hidden-danger.html
http://www.yourhealthbase.com/issue.htm
http://www.yourhealthbase.com/ihn228.pdf
Free full text PDF 16 pages
Fwd: Aspartame Submission from Prof. Woodrow C. Monte to EFSA: While Science Sleeps: A Sweetener Kills 241 p -- Ch 12 Autism and other Birth Defects 26 p -- 740 references full pdfs: Rich Murray 2011.11.03
http://rmforall.blogspot.com/2011/11/fwd-aspartame-submission-from-prof.html
http://www.whilesciencesleeps.com/While%20Science%20Sleeps%20-%20Chapter%2012%20\(ref).pdf
free Chapter 12 of the book "While Science Sleeps", "Autism and Other Birth Defects", with 100 free online full text references
Rich Murray
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
Rich Murray
254-A Donax Avenue, Imperial Beach, CA 91932-1918
rmforall@gmail.com
505-819-7388 cell
619-623-3468 home
rich.murray11 Skype audio, video
http://RMForAll.blogspot.com
Methanol/formaldehyde paradigm for multiple sclerosis, free full 56 page chapter 9 PDF, While Science Sleeps, 146 full text references online, Prof. Woodrow C. Monte: Rich Murray 2012.03.20
http://rmforall.blogspot.com/2012/03/methanolformaldehyde-paradigm-for.html
http://health.groups.yahoo.com/group/aspartameNM/message/1642
http://www.whilesciencesleeps.com/multiple-sclerosis-the-solution
Multiple Sclerosis: The Cause and the Solution Uncovered -- at Last!
An exhaustive analysis of the medical and scientific literature, authored by a uniquely qualified food scientist, persuasively reveals the cause of MS and describes a path to recovery and prevention.
The symptoms of Multiple Sclerosis are identical to those of an uncommon form of poisoning -- methanol poisoning. Individuals who have been exposed to this poison over a long period of time, in fact, develop MS. This poison -- methanol -- is a major component of cigarette smoke, which, until now, has been the only known cause of Multiple Sclerosis.
Dr. Monte's compelling work reveals that this poison is also contained in certain foods that are canned and smoked or have had the insidious sweetener, aspartame, added to them. Unfortunately, the truth has been obscured due to the fact that methanol is a poison only to humans and not to (laboratory) animals.
If you have MS, or love someone who does, you and your physician should read what Dr. Monte has to say about methanol and its link to MS. To expedite the free exchange of what might be lifesaving information about this disease, there is a file attached below to his website that contains a full copy of Chapter 9 of his book, While Science Sleeps. This chapter examines the cause of MS and posits the simple dietary changes that can save your life.
Download a free copy of Chapter 9 and have a read [99 pages, including list of all 740 full text online references for book -- Chapter 9 has 146 references]:
http://www.whilesciencesleeps.com/files/While%20Science%20Sleeps%20-%20Chapter%209%20(Prepublication%20copy)%20Website%203-15-2012.pdf The references are located on his website: http://www.whilesciencesleeps.com/references, as are the simple dietary changes that you must follow because your life may depend on it: http://www.whilesciencesleeps.com/monte-diet
. Everything you need to know about MS is in Chapter 9.
http://www.whilesciencesleeps.com/multiple-sclerosis
25 page slide show of 18 research studies showing huge increases in MS in women in warm countries since aspartame drinks became legal in the USA in July, 1983 -- especially in the hottest months of summer.
If you are interested in knowing more about methanol poisoning and its link to other diseases of civilization, you will want to read the entire book, While Science Sleeps, by Woodrow C. Monte PHD, Emeritus Professor of Nutrition and Food Science, Arizona State University.
Chapter 9:
Multiple Sclerosis
The Conflagration that is Multiple Sclerosis;
Listening to Nature’s Whispers;
The Scene of the Crime;
Location, Location, Location;
Details of Plaque Formation;
The Look, Touch, Taste and Smell of Multiple Sclerosis;
The Kitchen Autopsy;
The Cause of MS is within the Thickening Blood Vessels;
Symptoms Mean Little Unless They Are Identical in All Ways…Then They Mean Everything!;
Learn a Little About Arginine;
Myelin Basic Protein (MBP);
Looking for the Shadow of Formaldehyde;
“Woody… They Have Done Our Experiment for Us.… But They Just Don’t Get It!”;
Finding the Shadow of Formaldehyde in the MS Brain: The Smoking Gun (a Triple Blind Study);
Evidence That Methanol Causes MS;
The Etiology of Multiple Sclerosis -- Follow the Methanol;
A Food Scientist’s Nightmare Called Aspartame;
MS: a Disease of Colder Climates and Flush Toilets -- Before Aspartame;
A World Awash in MS after Aspartame;
Change in Frequency of MS by Sex:
the Methanol Source -- Food or Smoke -- Makes All the Difference;
Can Methanol Really Cause MS?;
MS Can Be Found in Some Places, but Cannot be Found in Others;
Industrial Exposure to Methanol -- Jobs that Can Last for an Eternity;
Teachers’ Paradigm;
MS Treatment -- Pharmaceutical Placeboes or Perhaps Worse;
Conclusion and Review;
Conclusion and Review
You can see for yourself now that the daily administration of methanol to the human organism does not go unnoticed by the immune system. The evidence is simply far too overwhelming for the pharmaceutical industries to credibly justify ignoring it any longer. As a scientist I can do little more than present a coherent molecular theory, and then prove the hypothesis using three paradigms with two distinct methods of methanol administration. Viewing methanol toxicity as the etiologic cause of MS answers all of the nagging questions and unexplained anomalies that have stalled the search for the cause of this disease. I realize that absolutely nothing can convince the pharmaceutical giants, who are now heavily invested in developing their own useless palliatives for MS, to give them up and rally around the methanol hypothesis. In the end, however, I believe that the truth will win out. Henry Miller prophesied over 50 years ago: It is possible that the cause of multiple sclerosis lies buried somewhere in these lengthy protocols waiting to be found by someone ingenious enough to unearth it.[#306]
Review
[http://www.whilesciencesleeps.com/pdf/224.pdf
224. Kim J, Mastronardi F, Wood D, Lubman D, Zand R, Moscarello M. Multiple Sclerosis: An important role for post-translational modifications of myelin basic protein in pathogenesis. Molecular & Cellular Proteomics 2003;2(7):453-62.
http://www.ncbi.nlm.nih.gov/pubmed/12832457 Abstract
http://www.mcponline.org/content/2/7/453.full?sid=4999b20c-f767-4934-88e4-7a8cc41ee4ca
Free html rich full text version]
The Monte methanol paradigm posits a simple, obvious major co-factor for many novel diseases of civilization -- vastly increasing the opportunity for extremely positive social service via avoiding all methanol sources: Rich Murray 2012.02.06
Methanol from smoking and aspartame, in humans alone, is always made into formaldehyde via the ADH enzyme inside the cells of blood vessels and many tissues -- a little alcohol protects.
Many novel diseases of civilization result since 1800 -- heart, stroke, Alzheimers, cancers, MS, autism, spina bifida – increasing rapidly with aspartame since 1981.
4 more positive reviews for While Science Sleeps, Prof. Woodrow C. Monte, on Amazon.com: Rich Murray 2012.02.26
http://rmforall.blogspot.com/2012/02/4-more-positive-reviews-for-while.html
http://health.groups.yahoo.com/group/aspartameNM/message/1641
While Science Sleeps, methanol from cigarettes and aspartame becomes formaldehyde inside human cells -- Table of Contents, WC Monte bio, Kindle electronic book version $ 9.80 Amazon.com: Rich Murray 2012.01.26
http://rmforall.blogspot.com/2012/01/while-science-sleeps-methanol-from.html
http://health.groups.yahoo.com/group/aspartameNM/message/1636
New book, concise opus "While Science Sleeps" life saving facts re aspartame (methanol, formaldehyde) -- 740 full text references are free online -- Woodrow "Woody" C. Monte, retired Prof. of Nutrition, Arizona State University: Rich Murray 2012.01.03
http://rmforall.blogspot.com/2012/01/new-book-concise-opus-while-science.html
http://health.groups.yahoo.com/group/aspartameNM/message/1631
http://www.WhileScienceSleeps.com
$ 37.98 text 236 pages -- 740 full text references free online -- Kindle electronic book, $ 9.80
http://www.amazon.com/review/RNGG3O7U33VCV
Rich Murray
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
Rich Murray
254-A Donax Avenue, Imperial Beach, CA 91932-1918
rmforall@gmail.com
505-819-7388 cell
619-623-3468 home
rich.murray11 Skype audio, video
http://RMForAll.blogspot.com